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Tau Protein Turnover

Meaning

Tau Protein Turnover is the continuous, regulated process of synthesis, post-translational modification, and degradation of the Tau protein within neurons. Tau is a microtubule-associated protein critical for stabilizing the internal structure and transport systems of the axon. A healthy, efficient turnover rate ensures the rapid clearance of old or hyperphosphorylated Tau, which prevents its misfolding and aggregation into neurofibrillary tangles. These tangles are a primary pathological hallmark of Alzheimer’s disease and other tauopathies. Maintaining optimal turnover is a key objective in neuroprotective strategies.