Targeted trophic factor delivery is a sophisticated therapeutic strategy focused on administering specific growth-promoting molecules directly to a compromised tissue, most commonly within the central nervous system. Trophic factors, such as Brain-Derived Neurotrophic Factor (BDNF) or Nerve Growth Factor (NGF), are essential for neuronal survival, differentiation, and synaptic plasticity. The goal of this targeted approach is to overcome the blood-brain barrier and achieve high local concentrations at the site of neurodegeneration or injury, minimizing systemic side effects.
Origin
The concept emerged from the discovery of neurotrophic factors in the mid-20th century, which established that nerve cells require chemical sustenance to survive. The need for targeted delivery became a major focus in the late 20th century, as researchers realized that these large protein molecules could not easily cross the protective blood-brain barrier from the systemic circulation.
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