What is the Origin of Targeted Senolytics?

The term is a compound of the Latin senex (old) and lytic (destroying), originating in the field of geroscience. The clinical development of these agents is based on the discovery that senescent cells accumulate with age and contribute significantly to chronic inflammation and tissue dysfunction.

What is the Mechanism of Targeted Senolytics?

Senolytic agents operate by disrupting the pro-survival pathways (e.g., anti-apoptotic proteins) that senescent cells rely upon to resist apoptosis. By inhibiting these specific pathways, the senescent cells are triggered to self-destruct. Their clearance by the immune system reduces the systemic inflammation drag and allows for healthier tissue regeneration, thereby improving tissue function and extending health span.

Targeted Senolytics ∞ Area

Targeted Senolytics

Meaning

Targeted Senolytics are a class of therapeutic compounds or strategies designed to selectively induce programmed cell death (apoptosis) in senescent cells—cells that have stopped dividing but remain metabolically active and secrete pro-inflammatory substances. The “targeted” aspect emphasizes the precision of eliminating these dysfunctional cells without harming healthy, non-senescent tissue. This approach is a core component of advanced longevity protocols aimed at clearing the cellular debris of aging.