What is the Origin of Targeted HRT?

The concept evolved in response to the clinical need for a more nuanced approach following large-scale studies that highlighted the risks associated with older, one-size-fits-all HRT regimens. The term "targeted" reflects the modern clinical emphasis on personalization and risk stratification, utilizing comprehensive lab testing and patient-specific data. This methodology aligns with the principles of precision medicine.

What is the Mechanism of Targeted HRT?

The mechanism relies on accurate biochemical assessment to identify specific hormone deficiencies and imbalances, which guides the choice of bioidentical or conventional hormones. The therapy is then administered via a route, such as transdermal or subcutaneous, that optimizes the hormone's metabolic pathway and minimizes first-pass liver effects. The goal is to restore the specific hormonal signaling cascades that support tissue health, such as bone density and neurocognitive function, with maximal therapeutic efficiency.

Targeted HRT ∞ Area ∞ Library 2

Targeted HRT

Meaning

Targeted Hormone Replacement Therapy (HRT) is a precision clinical approach to hormone management that customizes the specific type, dosage, and delivery route of hormone replacement based on an individual’s unique hormonal profile, symptom presentation, and risk factors. This strategy moves beyond standardized dosing to achieve optimal physiological hormone levels and symptom resolution while aiming to minimize potential adverse effects. It represents a personalized model of endocrine care. This approach is essential for modern, nuanced hormonal health.