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Targeted Estrogen Receptor Modulation

Meaning

Targeted Estrogen Receptor Modulation is a therapeutic strategy utilizing compounds, such as Selective Estrogen Receptor Modulators (SERMs) or tissue-selective estrogens, that function as agonists in some tissues and antagonists in others. The primary goal is to selectively leverage the beneficial, protective effects of estrogen in vital tissues like bone and brain while simultaneously minimizing or blocking its effects in potentially sensitive tissues such as the breast or endometrium. This allows for precise hormonal action with a significantly reduced systemic risk profile.