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Target Tissue Responsiveness

Meaning

Target Tissue Responsiveness refers to the functional sensitivity and magnitude of the biological reaction exhibited by a specific organ or cell population in response to a circulating hormone or signaling molecule. This is a crucial metric in endocrinology, as a high concentration of a hormone may be functionally meaningless if the target tissue receptors are down-regulated or post-receptor signaling pathways are impaired. Optimal responsiveness is essential for the effective communication and action of the endocrine system, determining the true impact of the hormonal signal.