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Tandem Mass Spectrometry

Meaning

A highly sophisticated analytical chemistry technique that involves the use of two mass spectrometers coupled in sequence, providing a powerful tool for the unambiguous identification and precise quantification of trace amounts of molecules within complex biological mixtures. In clinical endocrinology, Tandem Mass Spectrometry (LC-MS/MS or GC-MS/MS) is the gold standard for accurately measuring steroid hormones and their metabolites, offering superior sensitivity and specificity over traditional immunoassays. This precision is essential for effective hormonal health management.