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Tamoxifen in Men

Meaning

Tamoxifen in Men refers to the off-label, clinically supervised use of this Selective Estrogen Receptor Modulator (SERM), a drug primarily known for its role in breast cancer therapy, to treat specific endocrine conditions in male patients, most commonly secondary hypogonadism or gynecomastia. In the context of hormonal health, it is strategically used to significantly elevate the patient’s endogenous testosterone production by competitively blocking the potent negative feedback signal of estrogen at the central regulatory centers. This pharmacological strategy is an effective means of restoring the Hypothalamic-Pituitary-Gonadal (HPG) axis without the need for exogenous testosterone administration.