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Tamoxifen Hypothalamic Signaling

Meaning

This describes the specific pharmacological action of the drug tamoxifen, a Selective Estrogen Receptor Modulator (SERM), on the estrogen receptors located within the hypothalamus. By acting as an antagonist in this central brain region, tamoxifen blocks the negative feedback of estrogen, leading to an increase in gonadotropin release. This strategic manipulation of the central neuroendocrine axis is clinically utilized to elevate endogenous testosterone levels in men.