What is the Origin of TACR3?

The gene is part of the tachykinin receptor family, which is responsible for mediating the effects of neuropeptides like Neurokinin B, or NKB. Its critical role in human reproduction was elucidated through genetic studies in the early 21st century that identified inactivating mutations in patients with pubertal failure. This discovery firmly established the NKB/NK3R system as an essential central regulator of the hypothalamic-pituitary-gonadal, or HPG, axis.

What is the Mechanism of TACR3?

The NK3R functions as the receptor for the

TACR3 ∞ Area

TACR3

Meaning

TACR3, or Tachykinin Receptor 3, is a gene that encodes the Neurokinin 3 Receptor, or NK3R, a G-protein-coupled receptor centrally involved in the neuroendocrine control of human reproduction. This receptor is primarily expressed on kisspeptin neurons in the hypothalamus, acting as a critical component of the central pulse generator that drives the reproductive axis. Loss-of-function mutations in the TACR3 gene are directly linked to idiopathic hypogonadotropic hypogonadism, a condition characterized by a failure to undergo normal puberty due to insufficient secretion of gonadotropin-releasing hormone, or GnRH.