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Systems Biology of Metabolism

Meaning

Systems Biology of Metabolism is an interdisciplinary approach that analyzes the entire metabolic network as a complex, interconnected system rather than focusing on isolated biochemical pathways or single enzymes. This perspective integrates data from genomics, proteomics, metabolomics, and endocrinology to model how changes in one metabolic component—such as insulin signaling or mitochondrial function—cascade throughout the entire organism. The clinical goal is to identify the regulatory bottlenecks and control points within the metabolic system to implement targeted, high-leverage interventions. It offers a holistic view of energy and nutrient utilization.