The overarching structural and functional organization of the body’s integrated regulatory networks—primarily the neuroendocrine, metabolic, and immune systems—that collectively determine overall physiological vigor and resilience. This architecture describes the interdependent scaffolding supporting optimal healthspan. It is the blueprint for robust systemic function.
Origin
This term originates from complex systems theory applied to human physiology, emphasizing that health is an emergent property of interconnected subsystems rather than isolated organ function. The ‘architecture’ implies a designed, structured relationship between these components. It views health as a construct built from functional relationships.
Mechanism
The architecture relies on robust, bidirectional communication channels, such as the HPA axis regulating stress adaptation and the interplay between insulin sensitivity and muscle mass maintenance. Optimal function requires synchronized signaling where hormonal outputs are appropriate for the current metabolic demand state. Maintaining the integrity of these communication lines prevents cascading failures across the entire physiological network.
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