A therapeutic strategy involving the coordinated enhancement of multiple, interconnected biological processes and signaling pathways across the entire organism, leading to a net increase in overall physiological function and resilience. This is a holistic approach, moving beyond single-target intervention to achieve a widespread, measurable increase in cellular activity and homeostatic capacity. Systemic Upregulation is a core concept in regenerative and anti-aging medicine.
Origin
The term is derived from molecular biology, where “upregulation” refers to the increase in the expression of a gene or the activity of a pathway. “Systemic” extends this concept to the entire body, defining a comprehensive, multi-target therapeutic goal. It signifies a fundamental, positive shift in the body’s overall functional set point.
Mechanism
Systemic Upregulation is often achieved by modulating master regulatory pathways, such as the AMPK/mTOR axis, which govern cellular energy sensing and anabolic/catabolic balance. Interventions may target key endocrine signals, like growth hormone secretagogues or thyroid hormone optimization, to simultaneously boost metabolism, protein synthesis, and cellular repair across multiple tissues. This coordinated mechanism aims to elevate the entire physiological baseline.
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