Systemic Tissue Repair refers to the comprehensive, coordinated biological processes across multiple organ systems aimed at restoring integrity following injury, chronic inflammation, or normal wear and tear. This requires an optimal systemic signaling environment.
Origin
This concept arises from regenerative medicine, recognizing that effective local healing depends not just on the injured site but on systemic support provided by hormones, nutrients, and circulating progenitor cells.
Mechanism
Effective repair is driven by the presence of appropriate growth factors signaling through receptors, adequate systemic circulation for nutrient delivery to the site, and sufficient levels of anabolic hormones like IGF-1 and testosterone to facilitate cellular proliferation and matrix synthesis.
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