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Systemic Temporal Order

Meaning

The intricate, hierarchical organization and synchronization of all biological rhythms across the entire organism, encompassing the central circadian clock and the phase-locked peripheral clocks in various tissues, ensuring all physiological processes occur at their optimal time of day. This temporal order governs the timing of hormone release, gene expression, cell division, and metabolic activity, which is crucial for maintaining systemic health and resilience. Disruption to this order is known as chronodisruption and is a major contributor to metabolic and cardiovascular disease.