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Systemic Stressors

Meaning

Systemic stressors are any physical, psychological, or environmental challenges that impose a significant demand on the body’s overall physiology, requiring a coordinated, integrated adaptive response from multiple organ systems. These challenges can range widely from chronic inflammatory states and metabolic dysfunction to psychological trauma and prolonged periods of sleep deprivation. The body’s crucial adaptive response to these pervasive stressors is primarily orchestrated and mediated by the activation of the neuroendocrine system, particularly the Hypothalamus-Pituitary-Adrenal axis.