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Systemic Signaling Network Alteration

Meaning

A broad term describing the cascade of changes induced by exogenous hormones that extends beyond the primary target axis to influence numerous interconnected endocrine, paracrine, and autocrine communication pathways throughout the body. These alterations encompass changes in receptor sensitivity, circulating binding protein concentrations, and the expression of enzymes that regulate hormone metabolism in distant tissues. This phenomenon highlights the profound, interconnected nature of the human endocrine system and the wide-ranging impact of therapeutic intervention.