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Systemic Signal Persistence

Meaning

Systemic Signal Persistence refers to the sustained presence and biological activity of a therapeutic hormone or peptide within the body’s circulation and target tissues over a desired period. This critical pharmacokinetic characteristic ensures that the therapeutic message—the signal—is continuously available to its cognate receptors, driving a consistent and prolonged physiological response. Achieving high persistence is the primary goal of long-acting peptide formulations and is crucial for chronic conditions requiring stable hormonal levels. A longer persistence directly reduces the required dosing frequency.