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Systemic Senescence Mechanism

Meaning

Systemic Senescence Mechanism describes the overarching biological processes by which cellular aging, characterized by irreversible growth arrest and the secretion of pro-inflammatory factors, propagates throughout the body, ultimately driving organ and system dysfunction. This mechanism involves the accumulation of senescent cells in various tissues, leading to chronic low-grade inflammation, known as the Senescence-Associated Secretory Phenotype (SASP), which actively disrupts the function of neighboring healthy cells. In the hormonal context, this process directly impairs glandular function and reduces target tissue responsiveness. It is a fundamental driver of age-related endocrine decline.