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Systemic Safety

Meaning

Systemic Safety refers to the comprehensive, body-wide clinical assessment of a therapeutic agent or intervention, ensuring that its administration does not produce unacceptable or disproportionate adverse effects across the body’s various organ systems beyond the intended site of action. In the specialized context of hormonal health, this is a paramount clinical concern, requiring continuous monitoring of cardiovascular, hepatic, renal, and hematological function. Maintaining systemic safety is the core objective of pharmacovigilance and ethical, responsible clinical practice.