What is the Origin of Systemic Resilience Index?

Resilience, the ability to spring back, is applied to the entire physiological system, recognizing that health is not static but dynamic. The index integrates data from multiple physiological domains, reflecting the complexity of the body's self-regulatory mechanisms studied in endocrinology.

What is the Mechanism of Systemic Resilience Index?

The index is derived by analyzing physiological responses under controlled challenge, often using metrics like Heart Rate Variability recovery or post-exercise lactate clearance kinetics. The underlying mechanism relies on the swift and appropriate mobilization of counter-regulatory hormones like cortisol and catecholamines, followed by their efficient withdrawal once the stressor passes. High resilience means the endocrine system responds effectively without becoming exhausted or dysregulated by the transient load.

Systemic Resilience Index

Meaning

Systemic Resilience Index is a quantitative measure reflecting the body’s capacity to absorb physiological stressors—metabolic, inflammatory, or psychological—and rapidly return to a state of optimal homeostasis. A high index suggests robust adaptability driven by well-regulated endocrine and autonomic responses. This metric serves as a predictive indicator of healthspan, as lower resilience correlates strongly with increased vulnerability to pathology.