Skip to main content

Systemic Regulatory Failure

Meaning

Systemic Regulatory Failure describes a state of advanced physiological dysregulation where the body’s primary homeostatic control mechanisms—particularly the neuroendocrine and metabolic feedback loops—lose their ability to maintain stable internal conditions. This failure is characterized by chronic, uncorrected imbalances in multiple vital parameters, leading to a cascade of functional deficiencies and increased vulnerability to disease. It represents a significant loss of allostatic capacity across the entire biological system.