A comprehensive therapeutic strategy aimed at re-establishing optimal communication and balance across the major control systems of the body, particularly the neuroendocrine, metabolic, and immune systems. Adjustment moves beyond treating a single organ or hormone deficiency to harmonize the entire regulatory network, restoring efficient feedback loops and homeostatic control. This is the ultimate goal of functional and precision hormonal health.
Origin
This concept is rooted in systems biology and cybernetics, applying the principles of feedback control to the human organism. The term emphasizes the interconnectedness of biological systems and the need for a holistic approach to chronic dysregulation.
Mechanism
Adjustment involves the precise modulation of the HPA axis, the thyroid axis, and the gonadal axis, often through a combination of targeted hormonal support, stress mitigation techniques, and specific nutritional signaling. The primary mechanism is the restoration of central sensitivity to peripheral hormonal signals, such as pituitary responsiveness to thyroid and sex hormones. By recalibrating these master control centers, the entire downstream physiological network operates with greater efficiency and resilience, moving the patient toward optimal systemic balance.
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