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Systemic Regulation

Meaning

Systemic Regulation refers to the complex, integrated network of physiological control mechanisms that coordinate the function of multiple organs and systems throughout the entire body to maintain overall homeostasis. This intricate control is primarily mediated by the endocrine and nervous systems, which utilize hormones and neurotransmitters to transmit long-distance signals. Disruptions in systemic regulation can manifest as widespread, multi-organ dysfunction, often seen in chronic inflammatory or metabolic diseases. A clinical focus on systemic regulation involves addressing the body as an interconnected whole, rather than treating isolated symptoms.