What is the Origin of Systemic Re-Sensing?

The term is derived from the physiological concept of receptor sensitivity and feedback loops in endocrinology, with "Re-Sensing" highlighting the intentional clinical effort to restore this lost biological responsiveness. It addresses the fundamental problem of cellular communication failure in aging.

What is the Mechanism of Systemic Re-Sensing?

Interventions aimed at re-sensing, such as pulsed hormone delivery or specific nutrient timing, can upregulate the density and affinity of target tissue receptors, thereby improving the efficiency of hormonal signaling. For example, restoring insulin sensitivity allows cells to "re-sense" the metabolic signal, leading to improved glucose uptake and better overall energy regulation.

Systemic Re-Sensing ∞ Area

Systemic Re-Sensing

Meaning

Systemic re-sensing is the clinical process of recalibrating the body’s ability to accurately perceive and respond to its own internal and external biochemical signals, particularly those related to energy balance, stress, and hormonal feedback. This involves interventions that restore the sensitivity of cellular receptors and regulatory centers, such as the hypothalamus and pituitary gland, which may have become desensitized due to chronic stress or hormonal dysregulation. Re-sensing is a crucial step in restoring homeostatic control.