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Systemic Performance Degradation

Meaning

Systemic Performance Degradation is a clinical term describing the comprehensive, measurable decline in the functional capacity and resilience of multiple interconnected physiological systems, such as the neuroendocrine, metabolic, and cardiovascular systems, that occurs with chronological aging. This degradation is not merely a single organ failure but a synchronized loss of reserve capacity across the entire organism, making the individual increasingly vulnerable to stress and disease. In hormonal health, it is characterized by the simultaneous decline in anabolic hormones, compromised receptor sensitivity, and chronic low-grade inflammation. Reversing this degradation is the core objective of longevity medicine.