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Systemic Metabolic Derangement

Meaning

Systemic metabolic derangement refers to a broad, pathological state characterized by widespread dysfunction in the body’s fundamental processes of energy generation, utilization, and storage, often involving multiple organ systems. This condition is marked by significant imbalances in key metabolic parameters, such as insulin sensitivity, lipid profiles, and glucose homeostasis, extending beyond a single localized issue. Such derangement profoundly impacts endocrine function, as metabolic stress can disrupt the hypothalamic-pituitary axes, leading to hormonal dysregulation, including altered cortisol rhythms and reduced sex steroid production. Addressing this systemic issue is paramount for restoring overall hormonal health and longevity.