The comprehensive extension of the functional healthspan across all major organ systems, including the endocrine, cardiovascular, metabolic, and neurological networks, rather than merely focusing on the lifespan of the organism. Systemic longevity is achieved when the rate of biological aging is decelerated throughout the entire physiological architecture, resulting in robust, synchronized function and resilience to age-related diseases. This represents the ultimate goal of integrated health and wellness strategies.
Origin
This term is an evolution of the core concept of longevity, emphasizing the integrated, whole-body nature of the aging process, moving beyond single-gene or single-organ interventions. It is rooted in the clinical understanding that organ systems do not age in isolation but are interconnected through complex hormonal and metabolic signaling. The term demands a holistic approach to health optimization.
Mechanism
Achieving systemic longevity relies on the coordinated modulation of fundamental aging pathways across all tissues. This involves optimizing hormonal signaling, such as maintaining youthful levels of Growth Hormone and DHEA, while simultaneously enhancing cellular defense mechanisms like DNA repair and mitochondrial quality control. The mechanism is a global biological recalibration, promoting a state of cellular and organ-level homeostasis that resists the cumulative damage characteristic of chronological aging.
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