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Systemic Instruction Fidelity

Meaning

Systemic Instruction Fidelity is the measure of accuracy and clarity with which biological signals, such as hormones, neurotransmitters, and nutrient-sensing peptides, are generated, transmitted, and received across the body’s various tissues and organ systems. High fidelity ensures that a signal, such as an insulin release or a thyroid hormone pulse, elicits the correct, proportional response at the target cell level, leading to precise metabolic and physiological outcomes. Loss of fidelity, often due to chronic inflammation or receptor downregulation, results in metabolic resistance and hormonal dysfunction, which are hallmarks of chronic disease.