The concept describing the fidelity, clarity, and efficiency of communication networks throughout the entire biological system, encompassing hormonal signaling, neuronal transmission, and cellular crosstalk. High integrity means signals are sent, received, and interpreted accurately and rapidly, ensuring precise homeostatic control and coordinated organ function. Loss of integrity is a hallmark of aging and disease.
Origin
This term is an application of information theory to biology, where ‘systemic’ refers to the whole organism and ‘integrity’ refers to the completeness and accuracy of the information flow. In the context of endocrinology, it emphasizes that the quality of hormonal signaling is as important as the quantity of the hormone itself.
Mechanism
Integrity relies on the optimal function of hormone receptors, the absence of signal-blocking molecules, and the healthy structure of neuronal and vascular pathways. Age-related changes, such as receptor desensitization or myelin degradation, compromise this integrity. Interventions often target the cell membrane and receptor function to enhance sensitivity and restore the precise, rapid transmission of crucial endocrine and neuroendocrine commands.
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