What is the Origin of Systemic Information Dysregulation?

This conceptual term arises from functional medicine and integrative physiology, describing patterns of illness that do not fit neat diagnostic boxes based on single-organ pathology. It emphasizes that hormonal dysregulation is often intertwined with neural and immune system failures. The origin reflects a systems-based approach to chronic disease etiology.

What is the Mechanism of Systemic Information Dysregulation?

Dysregulation occurs when positive feedback loops become inappropriately sustained or negative feedback mechanisms fail to terminate signaling appropriately, for example, chronic HPA axis activation leading to cortisol resistance in peripheral tissues. This failure in information flow creates a state where the body receives conflicting or excessive regulatory signals, preventing efficient homeostatic restoration. Addressing this requires interventions that simultaneously stabilize multiple interconnected physiological systems.

Systemic Information Dysregulation ∞ Area

Systemic Information Dysregulation

Meaning

A state of widespread, non-specific disruption in the communication pathways across the body’s major regulatory systems, prominently involving endocrine feedback loops, autonomic nervous system tone, and inflammatory signaling cascades. This results in diffuse symptoms that resist localization to a single organ system, often seen in chronic fatigue or complex hormonal imbalances. We recognize this as a breakdown in integrated physiological communication.