The broad, multi-modal clinical strategy focused on decreasing the total cumulative burden of chronic, low-grade inflammation circulating throughout the body. This ‘load’ is measured by various inflammatory markers and is a major contributor to accelerated biological aging and chronic disease pathogenesis. Reduction is a core tenet of preventative medicine aimed at preserving tissue integrity and function.
Origin
This term integrates concepts from inflammation biology and clinical risk assessment, where ‘systemic’ refers to the whole body and ‘load’ quantifies the total inflammatory burden. The concept has gained prominence with the recognition of “inflammaging,” the age-related increase in systemic inflammation. Reduction is the clinical goal of minimizing this pro-aging factor.
Mechanism
Reduction protocols target the root causes of chronic inflammation, including visceral adiposity, gut dysbiosis, and chronic stress, all of which drive inflammatory cytokine release. Hormonal optimization is key, as restoring euthyroid status and balancing sex steroids often exerts a powerful anti-inflammatory effect. These interventions collectively downregulate key inflammatory signaling pathways, such as the NF-κB cascade, thereby lowering the overall systemic inflammatory burden and promoting cellular health.
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