What is the Origin of Systemic Inflammatory Attenuation?

This term is a core concept in immunometabolism and gerontology, combining the broad scope of 'systemic' inflammation with the action of 'attenuation,' which means to reduce the force or effect. The understanding of chronic low-grade inflammation, or "inflammaging," has led to clinical strategies focused on modulating this underlying process rather than merely treating symptoms. Hormones play a significant role in this modulation.

What is the Mechanism of Systemic Inflammatory Attenuation?

The mechanism is complex, involving the modulation of nuclear factor kappa B (NF-κB) signaling, a central regulator of inflammatory gene expression. Hormones such as cortisol, dehydroepiandrosterone (DHEA), and specific sex steroids possess anti-inflammatory properties, influencing immune cell differentiation and cytokine production. Attenuation also involves promoting gut barrier integrity and optimizing the balance of omega fatty acids to shift the eicosanoid profile toward a less inflammatory state.

Systemic Inflammatory Attenuation ∞ Area

Systemic Inflammatory Attenuation

Meaning

Systemic Inflammatory Attenuation is the therapeutic or physiological process of reducing the chronic, low-grade inflammatory state that pervades the entire organism and is a major driver of age-related disease. This attenuation involves the down-regulation of pro-inflammatory cytokines and the restoration of a balanced immune response. Successful attenuation is a key strategy for promoting healthspan and longevity.