What is the Origin of Systemic Inflammation Quenching?

This term combines the widespread nature of the target, "systemic inflammation," with the action of forceful suppression or extinguishing, "quenching." It is a vivid, clinical-translational term for anti-inflammatory therapy, emphasizing the goal of complete resolution rather than mere suppression.

What is the Mechanism of Systemic Inflammation Quenching?

The approach involves reducing the production of pro-inflammatory cytokines, promoting the synthesis of pro-resolving mediators like specialized pro-resolving mediators (SPMs), and restoring gut barrier integrity to reduce endotoxin translocation. By shifting the balance from a pro-inflammatory state to a pro-resolving state, the chronic activation of immune cells is dampened, protecting tissues from oxidative damage and metabolic dysfunction.

Systemic Inflammation Quenching

Meaning

A clinical strategy focused on the active reduction and resolution of chronic, low-grade, body-wide inflammation, which is often subclinical but highly detrimental to long-term health. Quenching involves the targeted use of anti-inflammatory agents, dietary modifications, and lifestyle changes to restore immunological homeostasis and lower circulating inflammatory biomarkers. It is essential for mitigating chronic disease risk and preserving tissue function.