Systemic Inflammation Profiling is a clinical diagnostic process that involves measuring a panel of specific circulating biomarkers to assess the overall, low-grade inflammatory burden across the entire physiological system. This analysis goes beyond simple markers like CRP, quantifying various acute-phase reactants, adhesion molecules, and inflammatory cytokines to reveal the precise nature and magnitude of chronic inflammation. This profile is an invaluable tool for identifying underlying drivers of hormonal dysfunction and accelerated aging.
Origin
The concept evolved from the study of chronic disease pathology, recognizing that persistent, low-grade inflammation is a common etiological factor in many age-related conditions. Profiling offers a multi-faceted, quantitative view of this complex biological state.
Mechanism
The profiling quantifies markers that reflect endothelial activation, immune cell mobilization, and tissue damage, such as high-sensitivity C-Reactive Protein (hs-CRP) and various interleukins. Elevated systemic inflammation directly impairs insulin signaling and increases the metabolic clearance rate of hormones like testosterone and thyroid hormone, thereby contributing to widespread endocrine dysregulation.
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