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Systemic Inflammation Measurement

Meaning

Systemic inflammation measurement is the clinical quantification of circulating inflammatory mediators and acute-phase reactants that reflect a state of chronic, low-grade, non-localized immune activation throughout the body. This smoldering inflammation, distinct from acute infection, is a key driver of age-related diseases, including cardiovascular pathology, insulin resistance, and neurodegeneration. Key clinical markers include high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and fibrinogen. Precise measurement allows clinicians to identify and target this foundational driver of biological aging and hormonal dysregulation.