What is the Origin of Systemic Inflammation Endocrine Link?

This concept evolved from the fields of immunometabolism and endocrinology, recognizing that immune cells and adipose tissue actively secrete signaling molecules that interfere with hormone action. The term highlights the critical interaction between the immune and endocrine systems, which were historically studied in isolation. This modern perspective frames chronic inflammation as a potent endocrine disruptor.

What is the Mechanism of Systemic Inflammation Endocrine Link?

Pro-inflammatory cytokines, such as TNF-alpha and Interleukin-6, released during systemic inflammation, interfere with insulin receptor signaling, leading to peripheral insulin resistance. These inflammatory mediators also suppress the hypothalamic-pituitary-thyroid (HPT) axis and the hypothalamic-pituitary-gonadal (HPG) axis, causing reduced production of active thyroid and sex hormones. This creates a vicious cycle where hormonal dysfunction further promotes the inflammatory cascade.

Systemic Inflammation Endocrine Link ∞ Area

Systemic Inflammation Endocrine Link

Meaning

The bidirectional pathological relationship where chronic, low-grade systemic inflammation directly impairs the function of the endocrine system, and, conversely, hormonal imbalances perpetuate the inflammatory state. This link is a key driver of many age-related and metabolic diseases, including insulin resistance, thyroid dysfunction, and hypogonadism. Understanding this connection is essential for treating the root cause of metabolic decline.