What is the Origin of Systemic Inflammation Downregulation?

This term arises from the field of immunometabolism, recognizing the crosstalk between adipose tissue, the immune system, and endocrine organs. Downregulation signifies the active suppression of this pathological inflammatory tone.

What is the Mechanism of Systemic Inflammation Downregulation?

Effective downregulation involves eliminating major inflammatory drivers, such as excess visceral adiposity or chronic psychological stress, which fuel cytokine production. Furthermore, it requires supporting the body's endogenous anti-inflammatory systems, ensuring appropriate sensitivity to anti-inflammatory mediators like cortisol.

Systemic Inflammation Downregulation

Meaning

Systemic Inflammation Downregulation is the clinical process of actively reducing chronic, low-grade inflammatory signaling present throughout the body that often undermines hormonal balance and cellular function. Persistent elevation of pro-inflammatory cytokines negatively impacts insulin sensitivity and steroidogenesis. Our goal is to return the immune system to a quiescent, homeostatic state.