Systemic Inflammation Clearance refers to the active physiological processes responsible for resolving widespread, low-grade inflammation and returning the immune system to a quiescent, homeostatic state. Effective clearance is essential because unresolved inflammation actively suppresses anabolic signaling and contributes to hormonal dysregulation, such as cortisol resistance. This clearance mechanism relies on the timely deactivation of pro-inflammatory pathways and the upregulation of anti-inflammatory regulators. Clinically, we assess clearance efficiency to determine overall metabolic resilience.
Origin
The term combines the broad scope of “systemic inflammation” with the functional concept of “clearance,” derived from immunology and septic shock research, applied to chronic, low-grade states. Its origin highlights the active resolution phase required for long-term health maintenance. It implies a necessary cleanup operation following a physiological challenge.
Mechanism
Clearance involves the induction of anti-inflammatory cytokines, such as IL-10, and the action of specialized pro-resolving mediators (SPMs) that actively terminate the inflammatory signal. Furthermore, healthy endocrine function supports this by ensuring appropriate glucocorticoid sensitivity, allowing cortisol to effectively dampen excessive immune activation. When this mechanism fails, perhaps due to chronic overstimulation or receptor desensitization, the inflammatory mediators persist, continuously signaling metabolic disruption.
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