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Systemic Inflammation Cascade

Meaning

The Systemic Inflammation Cascade describes the complex, widespread, and self-perpetuating sequence of biochemical events initiated by a chronic, low-grade inflammatory stimulus, often originating from excess visceral adipose tissue or gut dysbiosis, leading to the sustained release of pro-inflammatory cytokines like IL-6, TNF-alpha, and CRP into the general circulation. This persistent, non-resolving inflammatory state is a core pathological driver that directly impairs insulin signaling, accelerates cellular senescence, and disrupts the hypothalamic-pituitary-adrenal (HPA) axis, contributing significantly to metabolic and hormonal disease.