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Systemic Inflammation Brain Fog

Meaning

This clinical presentation describes a recognizable constellation of cognitive symptoms, including difficulty concentrating, impaired memory recall, and generalized mental sluggishness, that is directly driven by chronic, low-grade inflammation circulating throughout the entire body. The systemic inflammatory signals, primarily potent cytokines, can either cross the blood-brain barrier directly or activate peripheral immune cells that signal the brain, leading to localized neuroinflammation and altered neurotransmitter metabolism. This phenomenon clearly underscores the intimate and detrimental connection between immune dysregulation and core central nervous system function.