What is the Origin of Systemic Inflammation Biomarkers?

This terminology evolved from immunology and risk stratification, where identifying subclinical inflammation became crucial for predicting long-term health outcomes beyond traditional risk factors. Its origin is rooted in recognizing inflammation as a driver of chronic disease, including insulin resistance. These markers serve as objective readouts of immune system engagement.

What is the Mechanism of Systemic Inflammation Biomarkers?

High levels of these biomarkers indicate continuous activation of pro-inflammatory transcription factors, such as NF-kB, which can induce cellular resistance to crucial hormones like insulin and thyroid hormone. Furthermore, chronic inflammation can directly impair the function of endocrine glands or their target tissues by altering local tissue environments. The mechanism involves a persistent immune signaling cascade undermining metabolic homeostasis.

Systemic Inflammation Biomarkers ∞ Area

Systemic Inflammation Biomarkers

Meaning

Systemic Inflammation Biomarkers are quantifiable analytes, such as high-sensitivity C-Reactive Protein (hs-CRP) or specific cytokine levels, used to gauge the level of persistent, low-grade immune activation within the body. Elevated levels signal a state of chronic physiological stress that actively interferes with optimal endocrine signaling and metabolic flexibility. Monitoring these markers is essential for assessing overall wellness trajectory.