What is the Origin of Systemic Inflammation Baseline?

This term is derived from clinical immunology and endocrinology, recognizing that chronic, non-resolving inflammation is a core driver of non-communicable diseases. "Systemic" indicates the whole-body nature of the process, and "baseline" emphasizes the persistent, steady-state level of this activity. It links immune function directly to metabolic and hormonal health.

What is the Mechanism of Systemic Inflammation Baseline?

Adipose tissue dysfunction, particularly visceral fat accumulation, is a major source, releasing pro-inflammatory adipokines and cytokines that enter circulation. These inflammatory mediators interfere with insulin signaling pathways, promoting insulin resistance in muscle and liver cells. Chronic HPA axis overdrive and elevated cortisol can initially suppress inflammation but eventually lead to glucocorticoid resistance, further elevating the systemic baseline and accelerating metabolic and cardiovascular risk.

Systemic Inflammation Baseline ∞ Area

Systemic Inflammation Baseline

Meaning

The measurable, persistent, low-grade level of inflammatory activity present throughout the body in the absence of acute infection or injury, often quantified by circulating biomarkers such as high-sensitivity C-reactive protein (hs-CRP) or interleukins. This elevated baseline is not clinically acute but represents a chronic, subclinical immunological stressor that drives insulin resistance, endothelial dysfunction, and hormonal dysregulation. Maintaining a low baseline is a key marker of metabolic health.