What is the Origin of Systemic Inflammation and Hormones?

This concept bridges immunology and endocrinology, recognizing that the immune and endocrine systems are inextricably linked. The term highlights the critical role of inflammatory mediators in creating a state of hormonal resistance and dysregulation. It evolved from the clinical observation that many chronic diseases are characterized by both inflammation and endocrine imbalance.

What is the Mechanism of Systemic Inflammation and Hormones?

Pro-inflammatory cytokines, such as IL-6 and TNF-alpha, can directly inhibit the activity of the hypothalamus and pituitary gland, suppressing the HPG and HPT axes. They also interfere with insulin receptor signaling in peripheral tissues, leading to insulin resistance. Furthermore, inflammation alters the expression of sex hormone-binding globulin (SHBG), changing the bioavailability of sex steroids. This pervasive interference ultimately compromises the entire endocrine network.

Systemic Inflammation and Hormones ∞ Area

Systemic Inflammation and Hormones

Meaning

Systemic inflammation and hormones describes the bidirectional, pathological interaction where chronic, low-grade inflammation throughout the body disrupts the function and signaling of the endocrine system. Elevated circulating inflammatory cytokines interfere with hormone synthesis, metabolism, and receptor sensitivity. This interaction is a central driver of metabolic syndrome, insulin resistance, and reproductive dysfunction.