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Systemic Inflammation and Cognition

Meaning

The clinically observed and mechanistically linked phenomenon where chronic, low-grade elevation of circulating pro-inflammatory cytokines and immune mediators negatively impacts executive function, memory, and overall cognitive processing. This connection underscores the critical neuro-immune-endocrine axis, highlighting how peripheral inflammatory status can directly compromise central nervous system function. Mitigating systemic inflammation is therefore a key, foundational strategy for long-term cognitive health and neuro-longevity.