What is the Origin of Systemic Inflammaging Mitigation?

This phrase merges the concepts of immunosenescence and aging research, defining the chronic inflammatory state as 'inflammaging.' Mitigation focuses on intervention rather than passive management of age-related decline.

What is the Mechanism of Systemic Inflammaging Mitigation?

Mitigation involves targeting the cellular sources of pro-inflammatory cytokines, often through dietary modifications that balance fatty acid intake or the introduction of senolytics to clear senescent cells. Furthermore, optimizing gut microbiome balance can reduce the influx of inflammatory triggers that constantly stimulate the systemic immune response, allowing endocrine signaling fidelity to improve.

Systemic Inflammaging Mitigation ∞ Area

Systemic Inflammaging Mitigation

Meaning

Systemic Inflammaging Mitigation is the active, multi-modal clinical strategy aimed at reducing the chronic, low-grade, sterile inflammation characteristic of the aging process that impairs tissue function across the entire organism. This process seeks to restore immune system balance, thereby protecting vital endocrine glands and metabolic tissues from inflammatory damage. Effective mitigation is central to preserving long-term physiological performance.