What is the Origin of Systemic Inflammaging Control?

The term "Inflammaging" was coined in the early 2000s by Claudio Franceschi's research group, describing the persistent, low-level systemic inflammation observed in the elderly, even in the absence of overt infection. "Control" is the applied medical goal, integrating the findings of geroscience into actionable therapeutic protocols. It represents the paradigm shift toward viewing chronic inflammation as a modifiable driver of the aging process.

What is the Mechanism of Systemic Inflammaging Control?

Control is exerted by interrupting the pro-inflammatory feedback loops generated by senescent cells, which accumulate and secrete the Senescence-Associated Secretory Phenotype (SASP). Key mechanisms include modulating the gut microbiome to reduce intestinal permeability, suppressing the NLRP3 inflammasome, and enhancing mitochondrial function to reduce oxidative stress. Successful control restores the balance between pro- and anti-inflammatory networks, thereby preserving tissue function and immune competence.

Systemic Inflammaging Control ∞ Area

Systemic Inflammaging Control

Meaning

Systemic Inflammaging Control is the clinical and lifestyle strategy aimed at mitigating inflammaging, the chronic, low-grade, sterile inflammatory state that is a hallmark of biological aging. Control is achieved by actively reducing the production of pro-inflammatory cytokines and enhancing the body’s innate anti-inflammatory and repair networks. This intervention is a critical component of longevity medicine, directly targeting a root cause of age-related diseases and functional decline.