What is the Origin of Systemic Hormone Delivery?

The concept is central to pharmacokinetics and pharmacodynamics, emerging with the synthesis and clinical use of exogenous hormones in the early to mid-20th century. "Systemic" is derived from Greek systēma (organized whole), referring to the entire body, emphasizing the widespread distribution of the therapeutic agent.

What is the Mechanism of Systemic Hormone Delivery?

Different delivery methods, such as transdermal patches or oral tablets, influence the rate and extent of absorption, affecting the hormone's bioavailability and the pattern of plasma concentration. Systemic delivery is required when the therapeutic goal is to modulate the endocrine system broadly, such as in hormone replacement therapy, where the agent must interact with receptors in bone, brain, and other distant organs to restore overall hormonal balance and function.

Systemic Hormone Delivery

Meaning

The administration of hormonal agents via a route that results in the active substance entering the general circulation and reaching distant target tissues throughout the body, such as oral, transdermal, injectable, or implantable methods. This delivery contrasts with localized application, aiming for a broad physiological effect. It is the method of choice when the therapeutic goal is to modulate the entire endocrine system.