The active physiological process following a significant internal or external perturbation—such as illness, intense training, or nutritional deficit—where the body systematically adjusts its internal milieu back to its stable, functional set points. This restoration is heavily dependent on robust endocrine function and efficient molecular communication. It is the core goal of recovery.
Origin
Rooted in general physiology and Claude Bernard’s concept of internal milieu, “homeostasis” describes stability, and “re-establishment” implies the return to that stability. This is a continuous process modulated by hormonal feedback.
Mechanism
This involves the coordinated action of the autonomic nervous system and the endocrine system to adjust fluid balance, temperature, and substrate availability. For instance, after a period of high metabolic load management, the endocrine system must shift signaling to favor anabolism and repair. Effective re-establishment requires high fidelity in hormonal signaling to rapidly correct deviations.
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