The continuous, dynamic process of monitoring, regulating, and maintaining the stability of the body’s entire internal environment, ensuring that all physiological parameters, such as temperature, blood glucose, pH, and hormonal concentrations, remain within their optimal, narrow ranges. Effective systemic homeostasis management is a hallmark of robust health and is achieved through the coordinated action of the nervous and endocrine systems. This management is the ultimate goal of clinical interventions aimed at promoting healthspan and longevity.
Origin
This term is a clinical and therapeutic application of the fundamental physiological concept of “homeostasis,” coined by Walter Cannon, derived from the Greek words for “same” and “standing.” The addition of “systemic management” reflects a modern, comprehensive clinical approach that addresses the interconnectedness of all body systems, moving beyond single-point interventions.
Mechanism
The endocrine system plays a central role in this management through complex feedback loops. For example, when blood glucose rises, the pancreas releases insulin to lower it; when it falls, glucagon is released to raise it. These hormonal signals act on distant tissues to restore the set point. Stress hormones, such as cortisol, are deployed to coordinate a systemic response to external challenges, prioritizing survival functions and ensuring the maintenance of core stability across all organ systems.
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